Scientists at the Institute and Institute for Virus immunology Gladstone, San-Francisco, announced a new qualitative research surfen can reduce HIV transmission through sexual route.
Scientists at the Institute of Virus and Immunological Gladstone (GIVI) have discovered a new material capable of limiting the spread of HIV, known as "surfen", undermined the operation of the factors that enhance the ability of this virus in infected semen.
Scientists at the Institute of Virus and Immunological Gladstone (GIVI) have discovered a new material capable of limiting the spread of HIV, known as "surfen", undermined the operation of the factors that enhance the ability of this virus in infected semen.
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Surfen can be used as a supplement for HIV disinfectant, thereby dramatically reducing HIV transmission through sexual route.
Dr. Nadian Roan - advanced doctoral student in the lab discovered GIVI surfen - a small molecule limits the activity of a molecule po-li-ca-whiz Isaac HSPG called - are found found on the cell surface. The discovery was published in the Journal of Biological Chemistry.
Greene, colleagues of Dr. Roan said: "We are studying about SEVI, a naturally occurring element present in semen may help HIV can easily infect thousands of times. Surfent know, who stop SEVI, may allow us to lower the rate of HIV transmission. "
SEVI is a substance produced by prostate acid phosphate, a protein in semen. Under certain conditions, SEVI may increase HIV infection by up to 100,000 times for the virus to easily attach to target cells. Most HIV infection is the result of sex (in the process, sperm transport is HIV).
SEVI is clearly influenced by the rate of HIV infection, related to the SEVI link to the target cells and the spread of HIV-1 virus, but do not break the fibers SEVI.
Greene, colleagues of Dr. Roan said: "We are studying about SEVI, a naturally occurring element present in semen may help HIV can easily infect thousands of times. Surfent know, who stop SEVI, may allow us to lower the rate of HIV transmission. "
SEVI is a substance produced by prostate acid phosphate, a protein in semen. Under certain conditions, SEVI may increase HIV infection by up to 100,000 times for the virus to easily attach to target cells. Most HIV infection is the result of sex (in the process, sperm transport is HIV).
SEVI is clearly influenced by the rate of HIV infection, related to the SEVI link to the target cells and the spread of HIV-1 virus, but do not break the fibers SEVI.
Greene explained: "Because SEVI can enhance the ability of HIV infection, should a candidate for limiting it - surfen, can increase the effective prevention as a complement to reducing HIV" .
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Dr. Roan said: "SEVI has eight basic amino acids as it contains more positive charge. In previous studies, we show the ability of SEVI enhances the infection depends on a positive charge, it can affect the group in HSPG negative charge of the target cells. "
Scientists expect a rival to HSPG may interfere with binding of the virus and SEVI to target cells. They focus on surfen - first described in 1938 and is reported as potentially inflammatory and anti-bacterial activity.
The research team discovered that, surfen limit the increase of HIV-1 infection by SEVI clean or semen. Furthermore, they prove to surfen intervention of SEVI connection to the target cells and the HIV-1 infection.
Scientists expect a rival to HSPG may interfere with binding of the virus and SEVI to target cells. They focus on surfen - first described in 1938 and is reported as potentially inflammatory and anti-bacterial activity.
The research team discovered that, surfen limit the increase of HIV-1 infection by SEVI clean or semen. Furthermore, they prove to surfen intervention of SEVI connection to the target cells and the HIV-1 infection.
